Clinical Research

There were no significant differences between the ciNPT and SOC groups for baseline demographics; however, the ciNPT group had a higher proportion of severely obese patients (body mass index > 40 kg/m2) and patients who had two or more previous caesarean deliveries. The ciNPT group had a lower SSC rate compared to the SOC group (0/54 [0%] vs. 6/21 [21%], respectively; p=0.0011), as well as a lower number of surgical site infections (0/54 [0%] vs. 3/28 [11%]; p=0.037) and deep infections (0/54 [0%] vs. 3/28 [11%]; p=0.037).
Discussion:
In this patient population, ciNPT was well tolerated and may help improve clinical outcomes in high-risk patients undergoing caesarean delivery. Study limitations include retrospective design and potential selection bias, as only high-risk patients were included in the study. Large-scale randomized trials are needed to confirm these findings.