(LR-017) The Effect of Copper-Iodine Complex Solution on Relevant Microbial Pathogens in wound and burn care: An in vitro Kill Time and Antimicrobial Persistence Study at Body Temperature

Introduction: Copper-Iodine Complex Solution (CICS) an FDA cleared medical device indicated for the management of acute and chronic wounds and burns. One of the main reasons for wounds to stall in the inflammatory phase is advanced bioburden in the wound bed that alters the normal linear healing process. Mitigation or bioburden is essential to recalibrate the wound bed and allow the normal healing cascade to process. CICS is an important and instrumental medical device to reset the wound bed to achieve a healing trajectory.

Methods: In vitro methodology will be describe in detail to outline the assessment of Kill Time and Antimicrobial Persistence of CICS at 37 C, body temperature. Kill Time and antimicrobial Persistence will be determined by both time and log reduction. The Persistence evaluation will be determined by adding a log of 6 microorganisms at specific time points from 2 min to 72 hours without the addition of any further CICS.

Results: Over 20 relevant pathologic microorganisms that are know to inhibit wound and burn healing were evaluated. Kill Time and percent reduction ( >99.9999) will be reported for each microorganism. Persistence off the CICS over a period of 2 min to 72 hours will be documented. The results will demonstrate the ability of CICS to reduce and mitigate pathologic microorganisms in vitro as an antimicrobial preservative in solution. By doing so, it allows the pH of the wound bed to normalize, allow appropriate cellular activities to progress back to a linear healing trajectory. This is obviously in concert with other essential factors such as nutrition, edema, arterial flow, pressure relief, etc/

Discussion: Copper-Iodine Complex Solution demonstrated a very rapid Kill Time and most importantly, antimicrobial Persistence up to and including 72 hours. Again, this is achieved by the chemistry of CICS with "Chemistry ion Demand". Even though the chemistry contains iodine, the FDA has cleared CICS as non-cytotoxic. The equilibrium in the CICS allow for free iodine to be release when need or challenged to neutralize pathologic organisms when contacted in the solution. This is quite a unique attribute to a surgical irrigation solution to have this length of persistence without cytotoxicity, immunogenicity, and pyrogenicity. Further study are ongoing and clinical results are currently available.